| 2.1 Proportion of infants who achieve seizure control after the first loading dose of ASM |
3 |
286 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.69 [0.55, 0.86] |
| 2.2 Proportion of infants who achieve seizure control after the maximal loading dose of ASM |
3 |
260 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.58 [0.47, 0.72] |
| 2.3 Mortality before hospital discharge |
6 |
452 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.41 [0.82, 2.43] |
| 2.4 Requirement for mechanical ventilation |
5 |
394 |
Risk Ratio (M‐H, Fixed, 95% CI) |
2.20 [0.50, 9.68] |
| 2.5 Proportion of infants who develop sedation or drowsiness |
2 |
180 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.88 [0.66, 5.37] |
| 2.6 Bradycardia |
4 |
334 |
Risk Ratio (M‐H, Fixed, 95% CI) |
6.00 [0.74, 48.97] |
| 2.7 Hypotension requiring volume or inotropes |
2 |
130 |
Risk Ratio (M‐H, Fixed, 95% CI) |
Not estimable |
| 2.8 Shock requiring volume or inotropes |
3 |
190 |
Risk Ratio (M‐H, Fixed, 99% CI) |
0.67 [0.30, 1.51] |
| 2.9 Proportion of infants with an abnormal background pattern in EEG during ASM treatment |
1 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Totals not selected |
| 2.10 Proportion of infants with an abnormal background pattern in EEG after stopping ASM |
1 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Totals not selected |
| 2.11 Duration of hospital stay |
2 |
90 |
Mean Difference (IV, Fixed, 95% CI) |
2.36 [0.54, 4.18] |
| 2.12 Recurrence of seizure before hospital discharge |
2 |
130 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.67 [0.42, 6.60] |
| 2.13 Proportion of infants with persistent seizures and/or requiring ASM at discharge |
1 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Totals not selected |
| 2.14 Proportion of infants discharged on gavage feeds |
2 |
130 |
Risk Ratio (M‐H, Fixed, 95% CI) |
Not estimable |
| 2.15 Proportion of infants with an abnormal neurological examination at discharge |
4 |
272 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.80 [0.51, 1.24] |
| 2.16 Proportion of infants who develop epilepsy post discharge |
1 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Totals not selected |
