Comparison 7. Phenobarbital + bumetanide versus phenobarbital alone as first‐line ASM in EEG‐confirmed neonatal seizures.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
7.1 Proportion of infants who achieve seizure control after the first loading dose of ASM	1		Risk Ratio (M‐H, Fixed, 95% CI)	Totals not selected
7.2 Mortality before hospital discharge	1		Risk Ratio (M‐H, Fixed, 95% CI)	Totals not selected
7.3 Proportion of infants with cognitive impairment at 18‐24 months	1		Risk Ratio (M‐H, Fixed, 95% CI)	Totals not selected
7.4 Seizure burden during hospitalisation	1		Mean Difference (IV, Fixed, 95% CI)	Totals not selected
7.5 Requirement for mechanical ventilation	1		Risk Ratio (M‐H, Fixed, 95% CI)	Totals not selected
7.6 Hypotension requiring volume or inotropes	1		Risk Ratio (M‐H, Fixed, 95% CI)	Totals not selected
7.7 Proportion of infants with an abnormal background pattern in EEG during ASM treatment	1		Risk Ratio (M‐H, Fixed, 95% CI)	Totals not selected
7.8 Proportion of infants who develop epilepsy post discharge	1		Risk Ratio (M‐H, Fixed, 95% CI)	Totals not selected