Comparison 9. Maintenance ASM versus no maintenance ASM after achieving seizure control in clinically diagnosed neonatal seizures.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
9.1 Proportion of infants with repeat seizure before hospital discharge	2	373	Risk Ratio (M‐H, Fixed, 95% CI)	0.76 [0.56, 1.01]
9.2 Mortality before hospital discharge	2	373	Risk Ratio (M‐H, Fixed, 95% CI)	0.69 [0.39, 1.22]
9.3 Mortality at 18 to 24 months	1		Risk Ratio (M‐H, Fixed, 95% CI)	Totals not selected
9.4 Neurodevelopmental disability at 18 to 24 months' corrected age	1		Risk Ratio (M‐H, Fixed, 95% CI)	Totals not selected
9.5 Requirement for mechanical ventilation	1		Risk Ratio (M‐H, Fixed, 95% CI)	Totals not selected
9.6 Shock requiring volume or inotropes	2	373	Risk Ratio (M‐H, Fixed, 95% CI)	0.84 [0.67, 1.07]
9.7 Abnormal background pattern in EEG after achieving seizure control	1		Risk Ratio (M‐H, Fixed, 95% CI)	Totals not selected
9.8 Duration of hospital stay	2	373	Mean Difference (IV, Fixed, 95% CI)	0.13 [‐0.44, 0.70]
9.9 Proportion of infants with persistent seizures and/or requiring ASM at discharge	1		Risk Ratio (M‐H, Fixed, 95% CI)	Totals not selected
9.10 Abnormal neurological examination at discharge	2	373	Risk Ratio (M‐H, Fixed, 95% CI)	0.88 [0.62, 1.26]
9.11 Proportion of infants who develop epilepsy post‐discharge	1	126	Risk Ratio (M‐H, Fixed, 95% CI)	3.18 [0.69, 14.72]