#	Searches	Results
1	newborn/ or prematurity/ or newborn intensive care/ or newborn care/ or gestational age/	701545
2	(babe or babes or baby* or babies or gestational age? or infant? or infantile or infancy or low birth weight or low birthweight or neonat* or neo‐nat* or newborn* or new born? or newly born or premature or pre‐mature or pre‐matures or prematures or prematurity or pre‐maturity or preterm or preterms or pre term? or preemie or preemies or premies or premie or VLBW or VLBWI or VLBW‐I or VLBWs or LBW or LBWI or LBWs or ELBW or ELBWI or ELBWs or NICU or NICUs).ti,ab,kw,kf.	1116223
3	1 or 2 [neonates filter]	1353539
4	*anticonvulsive agent/	23296
5	*seizure/	40709
6	(anticonvuls* or anti‐convuls* or antiepileptic* or anti‐epileptic* or antiseizur*or anti‐seizur* or (seizur* adj2 prevent*) or seizur*).ti,ab,kw,kf.	238735
7	4 or 5 or 6 [terms for seizure]	247955
8	Randomized controlled trial/ or Controlled clinical study/	893379
9	random$.ti,ab,kw.	1776894
10	Randomization/	93533
11	placebo.ti,ab,kw.	334789
12	((double or single or doubly or singly) adj (blind or blinded or blindly)).ti,ab,kw.	248705
13	double blind procedure/	191703
14	(controlled adj7 (study or design or trial)).ti,ab,kw.	402960
15	parallel group$1.ti,ab.	29261
16	(crossover or cross over).ti,ab.	113486
17	((assign$ or match or matched or allocation) adj5 (alternate or group$1 or intervention$1 or patient$1 or subject$1 or participant$1)).ti,ab.	375586
18	(open adj label).ti,ab.	96587
19	(quasirandom* or quasi‐random* or randomi* or randomly).ti,ab,kw,kf.	1454219
20	(control* adj2 (group? or random*)).ti,ab,kw,kf.	1177241
21	8 or 9 or 10 or 11 or 12 or 13 or 14 or 15 or 16 or 17 or 18 or 19 or 20 [trials filter]	3030443
22	meta‐analysis/ or "systematic review"/ or "meta analysis (topic)"/	498280
23	((systematic* adj3 (review* or overview*)) or (methodologic* adj3 (review* or overview*))).ti,ab,kw.	326015
24	((integrative adj3 (review* or overview*)) or (collaborative adj3 (review* or overview*)) or (pool* adj3 analy*)).ti,ab,kw.	48224
25	(data synthes* or data extraction* or data abstraction*).ti,ab,kw.	42804
26	(hand search* or handsearch*).ti,ab,kw.	12732
27	(mantel haenszel or peto or der simonian or dersimonian or fixed effect* or latin square*).ti,ab,kw.	42052
28	(meta analy* or metanaly* or meta regression* or metaregression*).ti,ab,kw.	301073
29	(medline or cochrane or pubmed or medlars or embase or cinahl).ab.	362905
30	(cochrane or systematic review?).jn,jx.	30615
31	(overview adj2 reviews).ti.	108
32	22 or 23 or 24 or 25 or 26 or 27 or 28 or 29 or 30 or 31	776900
33	(2020* or 2021* or 2022*).yr.	4242025
34	32 and 33 [CADTH SR filter limited to the last 2 years]	200764
35	3 and 7 and 34 [results of the SR search]	171
36	3 and 7 and 21[results of the search for trials]	1962