| Study name |
To compare the effect of two anticonvulsant drugs levetiracetam and phenobarbitone in neonates with seizures |
| Methods |
Randomised controlled trial |
| Participants |
Neonates with clinical seizures not controlled after correction of hypoglycaemia and hypocalcaemia |
| Interventions |
Intervention1: Levetiracetam [LEV]: loading with LEV 20 mg/kg IV in neonates with seizures: if seizures stop, put on maintenance dose @ 20 mg/kg/day; if seizures continue, reload with LEV 20 mg/kg followed by maintenance dose of 40 mg/kg/day; if seizures still persist, switch over to phenobarbitone.
Control Intervention1: Phenobarbitone [PB]: loading with PB 20 mg/kg IV in neonates with seizures: if seizures stop, put on maintenance dose @ 3 mg/kg/day; if seizures continue, reload with PB 10 mg/kg followed by maintenance dose of 5 mg/kg/day; if seizures still persist, switch over to levetiracetam |
| Outcomes |
Cessation of seizures within 48 hours of administration of first or second loading dose of the drug [levetiracetam vs phenobarbitone], time point: 48 hours |
| Starting date |
2021 |
| Contact information |
drmanisha99@yahoo.com |
| Notes |
Clinical diagnosis of seizures and evaluation of treatment success |
