| Sharpe 2020 |
Low risk of bias |
Allocation concealed, sequence generation random and baseline characteristics does not reveal any imbalance between the two groups. |
Low risk of bias |
Though the personnel were aware of the intervention allocation, but there seems to be no deviations that arouse outside the trial context. Also all patients analysed as randomised. |
Low risk of bias |
Though there was missing data analysis methods that correct for bias such as sensitivity analyses showing that results are little changed under a range of plausible assumptions about the relationship between missingness in the outcome and its true value was performed |
Low risk of bias |
Being an objective outcome, it is unlikely that assessment of the outcome would be influenced by knowledge of allocation group |
Low risk of bias |
Trial analysed as per a priori registered protocol. |
Low risk of bias |
Low risk across all domains |
