| Sharpe 2020 |
Low risk of bias |
Allocation concealed, sequence generation random and baseline characteristics does not reveal any imbalance between the two groups. |
Low risk of bias |
Though the personnel were aware of the intervention allocation, but there seems to be no deviations that arouse outside the trial context. Also all patients analysed as randomised. |
Low risk of bias |
Though there was missing data analysis methods that correct for bias such as sensitivity analyses showing that results are little changed under a range of plausible assumptions about the relationship between missingness in the outcome and its true value was performed |
Some concerns |
Since the outcome is a subjective one and that the assessors were aware of the intervention, there is a likelihood of assessment being influenced by the knowledge of the allocation group |
Low risk of bias |
Trial analysed as per a priori registered protocol. |
Some concerns |
Some concerns in one domain |
