Risk of bias for analysis 7.2 Mortality before hospital discharge.

Study

Bias

Randomisation process

Deviations from intended interventions

Missing outcome data

Measurement of the outcome

Selection of the reported results

Overall

Authors' judgement

Support for judgement

Authors' judgement

Support for judgement

Authors' judgement

Support for judgement

Authors' judgement

Support for judgement

Authors' judgement

Support for judgement

Authors' judgement

Support for judgement

Soul 2021

Low risk of bias

Triple‐masked, sequence generation random and baseline characteristics does not reveal any imbalance between the two groups.

Low risk of bias

Double‐blinded study and neither the participants nor the treating physicians were aware of the allocation

Low risk of bias

Data reasonably complete for all the included patients

Low risk of bias

Triple‐masked trial

Low risk of bias

Trial analysed as per a priori registered protocol.

Low risk of bias

Low risk of bias across all domains