| Boylan 2004 |
Some concerns |
No information on allocation concealment, but baseline characteristics do not show any differences between the two groups. |
Low risk of bias |
Though there is no information on whether the allocation was blinded to participants or treating physicians, there were no significant deviations outside the trial context. Analysis was also as randomised. |
Low risk of bias |
Data reasonably complete for all the included patients |
Low risk of bias |
Being an objective outcome, it is unlikely that assessment of the outcome would be influenced by knowledge of allocation group |
Some concerns |
A trial protocol is not available for assessment |
High risk of bias |
Some concerns in more than one domain |
