Attanasio 2014.

Study characteristics
Methods	Study design: cluster‐RCT Duration of study: the study was conducted in 2010‐2011. Country: Colombia Income classification: upper‐middle‐income country in 2010‐2011 Geographical scope: 3 geographical regions proximal to Bogotá Healthcare setting: homes of the participants
Participants	1. Age: children aged 12 to 24 months; mothers aged 27.63 (6.96) years in control, 28.34 (6.95) in simulation group, 27.50 (6.23) in supplementation, 27.92 (6.55) in both intervention groups 2. Gender: both for children, female for caregivers 3. Socioeconomic background: not specified 4. Educational background: mothers’ mean ages of education 7.70 (3.51) in control, 7.21 (3.41) in simulation group, 7.41 (3.53) in supplementation, 7.48 (3.43) in both intervention groups Inclusion criteria: families with children aged 12‐24 months Exclusion criteria: none reported Note: at baseline, the intervention and control group scores for Center for Epidemiologic Studies Depression Scale Short Version (CES‐D‐10) were in the range of 8.38 to 9.61 depending on group allocation. Stated purpose: to assess the effectiveness of an integrated early child development intervention, combining stimulation and micronutrient supplementation
Interventions	Name: stimulation Title/name of PW and number: female community leaders 1. Selection: home visitors were selected from amongst the mother leaders of the communities. 2. Educational background: not specified 3. Training: they received training by 6 trained mentors (with an undergraduate degree in psychology social work or fieldwork experience with families and children). 4. Supervision: they received supervision by 6 trained mentors. 5. Incentives/remuneration: hired on a part‐time basis Prevention type: indicated – participants presented some level of distress as indicated by CES‐D scores. Intervention details Stimulation: the psychosocial stimulation programme was based on the Jamaican home visiting model, adapted for use in Colombia. Home visitors made weekly home visits where they demonstrated play activities using low‐cost or homemade toys, picture books, and form boards. These materials were left in the homes for the week after the visit and were changed weekly. The aims of the visits were to improve the quality of maternal‐child interactions and to assist mothers to participate in developmentally appropriate learning activities, many centred on daily routines. Supplementation: the micronutrient supplementation consisted of Sprinkles (Hexagon Nutrition, Mumbai, India) – encapsulated micronutrients in powder form – developed to treat childhood anaemia. Stimulation + supplementation: psychosocial stimulation and micronutrient supplementation Control: usual care
Outcomes	Participants’outcomes of interest for this review Depressive symptoms – CES‐D‐10 Carers’ outcomes of interest for this review Nil Economic outcomes Nil Time points: baseline, post‐intervention (not available) Note: data were not included in the meta‐analysis because they were not provided in the right format or were not available even after attempted author contact.
Notes	Source of funding: this study was funded by the Economic and Social Research Council (grant RES‐062‐23‐1548), Inter‐American Development Bank, World Bank, and International Growth Center. Notes on validation of instruments (screening and outcomes): the measure ES‐D is widely adopted and validated across contexts. Additional information: none Handling the data: not applicable Prospective trial registration number: ISRCTN18991160