Kuo 2020.

Study characteristics
Methods	Study design: RCT Duration of study: the study was conducted in 2015‐2017. Country: Cape Town, South Africa Income classification: upper‐middle‐income country from 2004 Geographical scope: urban community outside of Cape Town Healthcare setting: family‐friendly space in a community
Participants	1. Age: for adolescents, the average age was 14; caregivers were older than 18. 2. Gender: both 3. Socioeconomic background: not specified 4. Educational background: not specified Inclusion criteria—adolescents: a. 13‐15 years; b. concurs that the adult identified is their primary caregiver; c. when more than one child in the family falls within the eligible age range, one child will be chosen at random; d. lives in the household at least 4 days a week; e. subclinical thresholds of depressive symptoms. Inclusion criteria—caregivers: a. 18+ years; b. primary caregiver or the person responsible for childcare in the household on a day‐to‐day basis (as identified by the household); c. when more than one primary caregiver exists in the household, one will be chosen at random; lives in the household at least 4 days a week; d. subclinical thresholds of depressive symptoms. Exclusion criteria: a. cognitive impairments that would not allow them to provide informed consent or assent; b. if they participated in qualitative phases of the study; c. report no or low symptoms or clinically significant thresholds of depression. Note: at baseline, total sample scores for the Center for Epidemiologic Studies Depression Scale (CES‐D) were 12.11 (2.05). Stated purpose: to assess the acceptability, feasibility, and preliminary efficacy of Our Family Our Future, a resilience‐oriented intervention engaging families in the prevention of adolescent HIV and depression
Interventions	Name: Our Family Our Future Title/name of PW and number: facilitators (2) 1. Selection: significant prior experience interacting with adolescents and families affected by HIV and poor mental health 2. Educational background: bachelor’s and master’s level training 3. Training: training occurred through an initial two‐week interactive didactic seminar and completion of a mock course of intervention delivery. 4. Supervision: weekly support was provided during the intervention delivery. 5. Incentives/remuneration: not specified Prevention type: indicated – participants were included if they presented subclinical thresholds of depressive symptoms; all those who report no or low symptoms or clinically significant thresholds of depression were excluded. Intervention details: Our Family Our Future is a ‘selective’ behavioural prevention programme, designed to address HIV/STI acquisition, sexual risk behaviour, and depression among adolescents (ages 14‐16) in communities with high HIV prevalence and from families where adolescents and parents already exhibit mild, potentially troublesome, depressive symptoms but do not reach the threshold for further screening for a significant clinical depressive disorder. This intervention involves parent‐child dyads who receive the intervention in a community setting, in a facilitated group format. The intervention is composed of 3‐hour sessions, held weekly for 3 consecutive weeks with an individual family meeting in the third or fourth week depending on family desires. Control: waiting list – participants are offered usual care and delivered the intervention at the end of the study.
Outcomes	Participants’outcomes of interest for this review Depressive symptoms – CES‐D Carers’ outcomes of interest for this review Nil Economic outcomes Nil Time points: baseline, post‐intervention (< 1 month, 1‐6 months) Note: data were not included in the meta‐analysis because they were not provided in the right format or were not available even after attempted author contact.
Notes	Source of funding: not specified Notes on validation of instruments (screening and outcomes): the scale (CES‐D) was validated for use in the local population. Additional information: none Handling the data: not applicable Prospective trial registration number: NCT02432352