Table 3.
Cox regression analysis of risk factors associated with SAP and the relative abundance of specific taxa
| Risk factor | Univariate analysis | Multivariate analysis* | Multivariate analysis# | |||||
|---|---|---|---|---|---|---|---|---|
| HR(95% CI) | P value | Model 1 aHR(95% CI) | P value | Model 2 aHR(95% CI) | P value | |||
| Protective bacteria | ||||||||
| p__Firmicutes | 0.016(0.002–0.160) | <0.001 | NA | NA | NA | NA | ||
| c__Bacilli | 0.090(0.028–0.290) | <0.001 | 0.190(0.042–0.864) | 0.032 | 0.139(0.035–0.552) | 0.005 | ||
| o__Lactobacillales | 0.095(0.031–0.292) | <0.001 | 0.183(0.044–0.766) | 0.020 | 0.154(0.043–0.557) | 0.004 | ||
| f__Streptococcaceae | 0.125(0.043–0.367) | <0.001 | 0.223(0.063–0.794) | 0.021 | 0.184(0.056–0.602) | 0.005 | ||
| g__Streptococcus | 0.125(0.043–0.367) | <0.001 | 0.223(0.063–0.794) | 0.021 | 0.184(0.056–0.602) | 0.005 | ||
| Hazardous bacteria | ||||||||
| p__Bacteroidota | 4.732(1.434–15.618) | 0.011 | NA | NA | NA | NA | ||
| c__Bacteroidia | 4.735(1.435–15.636) | 0.011 | NA | NA | NA | NA | ||
| o__Bacteroidales | 4.557(1.492–13.913) | 0.008 | NA | NA | NA | NA | ||
| f__Prevotellaceae | 4.147(1.559–11.032) | 0.004 | NA | NA | NA | NA | ||
| g__Prevotella | 4.508(1.781–11.778) | 0.002 | NA | NA | 3.224(1.147–9.063) | 0.026 | ||
| F/B | 0.254(0.107–0.601) | 0.002 | NA | NA | NA | NA | ||
| S/P | 0.345(0.202–0.590) | <0.001 | NA | NA | 0.424(0.231–0.776) | 0.005 | ||
*adjusted by age, initial NIHSS score, enteral nutrition, atrial fibrillation, dysphagia, and NLR(neutrophil to lymphocyte ratio)
#adjusted by A2DS2 score
F/B Firmicute/Bacteroidota (F/B) ratio; S/P Streptococcus/Prevotella (S/P) ratio