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. 2023 Oct 24;21:746. doi: 10.1186/s12967-023-04610-9

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Diagram summarizing the experimental steps of editing POU5F1 (OCT4) locus in mouse zygote (green) and human zygote (blue) using the CRISPR-Cas9 strategy. Different effects on human embryo development were compared in the presence and absence of the OCT4 gene. The role of OCT4 was also compared between mouse and human embryo development