Table 2.
Disease symptoms and signs
| Interventional cohort | Observational cohort | P-value | |||
|---|---|---|---|---|---|
| N | n (%) | N | n (%) | ||
| Fever | 98 | 77 (78.6%) | 203 | 158 (77.8%) | 0.99 |
| Respiratory symptoms | 98 | 80 (81.6%) | 203 | 160 (78.8%) | 0.65 |
| Radiological evidence of pneumonia | 98 | 97 (99.0%) | 203 | 201 (99.0%) | 0.99 |
| Respiratory rate > 30 | 98 | 5 (5.1%) | 203 | 7 (3.4%) | 0.54 |
| Oxygen saturation < 93% | 98 | 34 (34.7%) | 203 | 72 (35.5%) | 0.99 |
| PaO2/FiO2 < 300 | 98 | 33 (33.7%) | 203 | 98 (48.3%) | 0.02 |
| Respiratory failure requiring invasive ventilation | 98 | 0 (0.0%) | 203 | 2 (1.0%) | 0.99 |
| Septic shock | 98 | 0 (0.0%) | 203 | 0 (0.0%) | n/a |
| Multiorgan failure | 98 | 0 (0.0%) | 203 | 0 (0.0%) | n/a |
| Fever > 38.3 °C | 98 | 41 (41.8%) | 203 | 64 (31.5%) | 0.09 |
| Cough | 98 | 61 (62.2%) | 203 | 109 (53.7%) | 0.17 |
| Dyspnoea | 98 | 43 (43.9%) | 203 | 106 (52.2%) | 0.18 |
| Fatigue | 98 | 40 (40.8%) | 203 | 78 (38.4%) | 0.71 |
| Myalgia | 98 | 31 (31.6%) | 203 | 25 (12.3%) | < 0.001 |
| Anosmia/Ageusia | 98 | 24 (24.5%) | 203 | 13 (6.4%) | < 0.001 |
| Nausea/Vomiting | 98 | 9 (9.2%) | 203 | 16 (7.9%) | 0.82 |
| Diarrhoea | 98 | 18 (18.4%) | 203 | 30 (14.8%) | 0.50 |
| Conjunctivitis | 98 | 3 (3.1%) | 203 | 3 (1.5%) | 0.40 |
| Confusion | 98 | 4 (4.1%) | 203 | 18 (8.9%) | 0.16 |
| Headache | 98 | 17 (17.3%) | 203 | 15 (7.4%) | 0.02 |