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. 2023 Oct 10;4:1261121. doi: 10.3389/fragi.2023.1261121

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Copyright © 2023 Petrashen, Lin, Kun and Kreiling.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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miR-465 attenuates GH signaling in vivo. Injection of a mir-465 mimic into the tail vein results in accumulation in the liver in (A) male and (B) female mice, shown as expression level normalized to snord66 and snord70. (C) GHR mRNA is enriched in a streptavidin pulldown of a biotinylated mir-465 mimic injected into the tail vein. Injection of a mir-465 mimic leads to a reduction in (D) GHR mRNA, (E) IGF-1 mRNA, (F) IGFALS mRNA, and (G) IGFBP3 mRNA in both male and female mouse liver after 4 days. All mRNA expression levels were normalized to GAPDH and HPRT. Error bars represent S.E.M.; n = 4–9. ***, p < 0.001; **, p < 0.01; *, p < 0.05.