TABLE 1.
Chimeric receptors
| Chimeric Receptor | Effect | Source |
|---|---|---|
| β2-AR | Increased cAMP Decreased network firing CPP when activated on NAc Shell neurons |
(Kim et al., 2005) (Airan et al., 2009) |
| α1AR | Increased PLC activity Increased neural activity | (Airan et al., 2009) |
| 5HT1A | Mimics native 5HT1A expression pattern Neuronal hyperpolarization |
(Oh et al., 2010) |
| μ-Opioid | Decreased calcium influx Decreased AC activity Increased GIRK conductance Decreased neuronal excitability Decreased sucrose consumption when activated on DRN terminals in the NAc |
(Barish et al., 2013) (Siuda et al., 2015a) (Castro et al., 2021) |
| D1R | Increased cAMP Increased social preference when expressed on D1R+ NAc neurons | (Gunaydin et al., 2014) |
| β2-ARLYY β2-ARSS | Arrestin- and G protein–biased β2-AR Increased in phosphor-ERK and cAMP, respectively |
(Siuda et al., 2015b) |
| Adenosine2A | Increased cAMP, phospho-MAPK, and phosphor-CREB Increased spatial memory performance when activated on hippocampal neurons |
(Li et al., 2015) |
| mGluR6 | Increased GIRK currents Restoration of vision when expressed on ON-Bipolar retinal neurons |
(van Wyk et al., 2015) |
| 5HT2A | Neuronal hyperpolarization Mimics native 5HT2A expression pattern | (McGregor et al., 2016) (Eickelbeck et al., 2019) |
| Orphan GPCRs | Varied | (Morri et al., 2018) |