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. 2023 Nov;75(6):1119–1139. doi: 10.1124/pharmrev.122.000584

TABLE 2.

Photopharmacology

Type Receptor/Effect Source
Caged Glutamate/agonist (Callaway and Katz, 1993) (Ellis-Davies, 2007)
Caged Adrenergic/agonists (Muralidharan and Nerbonne, 1995)
Caged GABA/agonist (Gee et al., 1994)
Caged μ- and λ-opioid/agonists (Banghart and Sabatini, 2012) (Banghart et al., 2018)
Caged D1R and D2R/agonists and antagonists (Araya et al., 2013) (Gienger et al., 2020)
Caged mGluR5/NAM (Font et al., 2017)
Diffusible photoswitchable mAChR M1-5/antagonist (Nargeot et al., 1982)
Diffusible photoswitchable mGluR5/NAM (Pittolo et al., 2014)
Diffusible photoswitchable A2A/partial agonist (Bahamonde et al., 2014)
Diffusible photoswitchable μ-opioid/agonist (Schönberger and Trauner, 2014)
Diffusible photoswitchable mGluR5/NAM (Pittolo et al., 2014)
Diffusible photoswitchable GLP-1/agonist (Broichhagen et al., 2015b, 2016)
Diffusible photoswitchable mGluR4/NAM and PAM (Rovira et al., 2016)
Diffusible photoswitchable mAChR M1/agonist (Agnetta et al., 2017)
Diffusible photoswitchable GPR40/ agonist (Frank et al., 2017)
Diffusible photoswitchable D1R and D2R/agonist (Lachmann et al., 2017)
Diffusible photoswitchable CB1/agonist (Westphal et al., 2017)
Diffusible photoswitchable CXCR3/agonist and antagonist (Gómez-Santacana et al., 2018, 2019)
Diffusible photoswitchable Histamine H3/agonist (Hauwert et al., 2018)
Diffusible photoswitchable CB2/agonist (Sarott et al., 2021)
Diffusible photoswitchable mGluR2/PAM (Donthamsetti et al., 2021a)
Diffusible photoswitchable 5HT2A/agonist (Gerwe et al., 2022)
Tethered photoswitchable mAChR/agonist (Lester et al., 1980) (Chabala and Lester, 1986)
Tethered photoswitchable Shaker K+/antagonist (Chambers et al., 2006)
Tethered photoswitchable nAChR/agonist and antagonist (Tochitsky et al., 2012) (Damijonaitis et al., 2015)
Tethered photoswitchable mGluR2/agonist and antagonist (Levitz et al., 2013)
Tethered photoswitchable D1R and D2R/agonist (Donthamsetti et al., 2017)
Remotely tethered photoswitchable mGluR2/agonist (Broichhagen et al., 2015a).
Remotely tethered photoswitchable mGluR6–8/agonist (Levitz et al., 2017)
Remotely tethered photoswitchable (nanobody) mGluR2/agonist (Farrants et al., 2018)
Remotely tethered photoswitchable mGluR2/agonist (Acosta-Ruiz et al., 2020) (Gutzeit et al., 2021)
Remotely tethered photoswitchable GPR55/agonist (Tobias et al., 2021)
Remotely tethered photoswitchable D1R /agonist (Donthamsetti et al., 2021b)
Remotely tethered photoswitchable 5HT2A/agonist (Morstein et al., 2022)