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Potency rank order for opioids for producing antinociception, respiratory depression, and constipation following i.c.v. administration
| Opioid | Rank Order of Potency |
|---|---|
| Morphine | Antinociception > respiratory depression > constipation |
| Oxycodone | Antinociception > constipation > respiratory depression |
| Fentanyl | Antinociception > constipation > respiratory depression |
| Buprenorphine | Constipation > respiratory depression > antinociception |
Table adapted from Kuo et al. (2015).
