TABLE 3.
Drugs, drug classes, and clinical use for interaction studies with oxycodone
| Drug(s) | Class - Clinical Use |
|---|---|
| Clozapine, Quetiapine, Risperidone | Atypical Antipsychotics |
| Diazepam | Benzodiazepine - Anxiety |
| Zolpidem | Imidazopyridine - Insomnia |
| Trazodone | Serotonin receptor antagonist and reuptake inhibitor - Major Depressive Disorder |
| Carisoprodol – Cyclobenzaprine | GABA - Tricyclic - Serotonin 5-HT2 receptor antagonist - Skeletal muscle relaxants |
| Mirtazapine | Atypical Tricyclic Antidepressant |
| Topiramate | Blocks voltage-gated sodium channels & enhances GABA receptor activity - Anticonvulsant |
| Paroxetine – Duloxetine | Selective serotonin reuptake inhibitor - Serotonin & norepinephrine reuptake inhibitor - Depression |
| Ramelteon | Melatonin receptor antagonist - Insomnia |
| Suvorexant | Orexin receptor antagonist - Insomnia |
Table adapted from Xu et al. (2021); copyright CC-BY-NC-ND.