TABLE 1.
Human nuclear receptor superfamily
| Group | Common Name | Abbreviation | Aliases | Natural Ligand(s) |
|---|---|---|---|---|
| Atypical NRs | Dosage-sensitive sex reversal-adrenal hypoplasia critical region on chromosome X, gene 1 | DAX1 | NR0B1, AHC, AHCH, AHX, DSS, GTD, HHG, SRXY2 | Orphan |
| Short heterodimeric partner | SHP | NR0B2, SHP1 | Orphan | |
| I | Thyroid hormone receptor-α | TRα | NR1A1, THRA | Thyroid hormones |
| Thyroid hormone receptor-β | TRβ | NR1A2, THRB | Thyroid hormones | |
| Retinoic acid receptor-α | RARα | NR1B1, RARA | Retinoic acids | |
| Retinoic acid receptor-β | RARβ | NR1B2, RARB | Retinoic acids | |
| Retinoic acid receptor-γ | RARγ | NR1B3, RARG | Retinoic acids | |
| Peroxisome proliferator activated receptor-α | PPARα | NR1C1, PPARA | Fatty acids | |
| Peroxisome proliferator activated receptor-δ | PPARδ | NR1C2, PPARD, PPARβ | Fatty acids | |
| Peroxisome proliferator activated receptor−γ | PPARγ | NR1C3, PPARG | Fatty acids | |
| Reverse-Erb-α | REV-ERBα | NR1D1, EAR1 | Heme | |
| Reverse-Erb-β | REV-ERBβ | NR1D2, EAR-1R | Heme | |
| Retinoic acid-related orphan-α | RORα | NR1F1, RORA | Sterols | |
| Retinoic acid-related orphan-β | RORβ | NR1F2, RORB | Sterols | |
| Retinoic acid-related orphan-γ | RORγ | NR1F3, RORC | Sterols | |
| Farnesoid X receptor-α | FXRα | NR1H4, BAR, HRR1 | Bile acids | |
| Liver X receptor-α | LXRα | NR1H3, LXRA | Oxysterols | |
| Liver X receptor-β | LXRβ | NR1H2, LXRB | Oxysterols | |
| Vitamin D receptor | VDR | NR1I1, PPP1R163 | 1α,25-dihydroxyvitamin D3 | |
| Pregnane X receptor | PXR | NR1I2, SXR, BXR | Endobiotics, xenobiotics | |
| Constitutive androstane receptor | CAR | NR1I3, CAR1, MB67 | Androstenol, androstanes, xenobiotics | |
| II | Hepatocyte nuclear factor-4-α | HNF4α | NR2A1, HNF4A | Fatty acids |
| Hepatocyte nuclear factor-4-γ | HNF4γ | NR2A2, HNF4G | Fatty acids | |
| Retinoid X receptor-α | RXRα | NR2B1, RXRA | 9-cis retinoic acid | |
| Retinoid X receptor-β | RXRβ | NR2B2, RXRB, RCoR-1 | 9-cis retinoic acid | |
| Retinoid X receptor-γ | RXRγ | NR2B3, RXRG, RXRC | 9-cis retinoic acid | |
| Testicular receptor 2 | TR2 | NR2C1 | Orphan | |
| Testicular receptor 4 | TR4 | NR2C2, TAK1 | Unsaturated fatty acids | |
| Tailless homolog orphan receptor | TLX | NR2E1, TLL, XTLL | Orphan | |
| Photoreceptor cell-specific nuclear receptor | PNR | NR2E3, RNR, ESCS | Orphan | |
| Chicken ovalbumin upstream promoter-transcription factor I | COUP-TFI | NR2F1, COUPTFA, SVP44, COUP-TF1 | Orphan | |
| Chicken ovalbumin upstream promoter-transcription factor II | COUP-TFII | NR2F2, COUPTFB, SVP40, COUP-TF2 | Orphan | |
| V-ErbA-related protein 2 | EAR-2 | NR2F6, ERBAL2 | Orphan | |
| III | Estrogen receptor-α | ERα | NR3A1, ESR1, ESRA | Estrogens |
| Estrogen receptor-β | ERβ | NR3A2, ESR2, ESRB | Estrogens | |
| Estrogen Receptor-related receptor-α | ERRα | NR3B1, ERR1, ESRRA | Cholesterol, estradienolone | |
| Estrogen Receptor-related receptor-β | ERRβ | NR3B2, ERR2, ESRRB | Orphan | |
| Estrogen Receptor-related receptor-γ | ERRγ | NR3B3, ERR3, ESRRG | Estradienolone | |
| Androgen receptor | AR | NR3C4, DHTR, AR8 | Androgens | |
| Glucocorticoid receptor | GR | NR3C1, GCCR, GCR | Glucocorticoids | |
| Mineralocorticoid receptor | MR | NR3C2, MCR, MLR | Mineralocorticoids and glucocorticoids | |
| Progesterone receptor | PR | NR3C3, PGR | Progesterone | |
| IV | Nerve growth factor 1B | NGFI-B | NR4A1, NUR77, GFRP1 | Unsaturated fatty acids |
| Nurr-related factor 1 | NURR1 | NR4A2, RNR1, NOT | Unsaturated fatty acids, 5,6-dihydroxyindole |
|
| Neuron-derived orphan receptor 1 | NOR-1 | NR4A3, CHN, CSMF | Orphan | |
| V | Steroidogenic Factor 1 | SF-1 | NR5A1, FTZ1, ELP | Phospholipids |
| Liver receptor homolog-1 | LRH-1 | NR5A2, FTZ-F1beta | Phospholipids | |
| VI | Germ cell nuclear factor | GCNF | NR6A1, RTR, CT150 | Orphan |