Fig 2.

Allelic frequency of drug resistance-conferring mutations detected in identified minority M. tuberculosis variants. DR: drug resistant (majority variants resistant to any first-line TB drugs); DS: drug susceptible (majority variants susceptible to all first-line TB drugs); DR-MVs: drug-resistant minority variants; LPA: line probe assay; pDST: phenotypic drug-susceptibility testing; WGS: whole genome sequencing. Horizontal red line (at 3%) and dashed lines indicate the limit of detection of minority variants for each method.