Figure 5.

Genes that drive core enrichment-significant results for this branching morphogenesis pathway (Gene Ontology 0048754). This VEGAS2 analysis Gene Set Enrichment Analysis plot includes 32 genes that are in three key signaling pathways (Shh [25]; TGFb [26]; and Wnt [27]) for lung development (including branching morphogenesis) and/or interact with genes in those three signaling pathways and/or have other roles in lung development (shown in bold). The 18 genes that are associated with lung repair and/or play a role in molecular pathogenic aspects of lung disorders (e.g., chronic obstructive pulmonary disease, asthma, lung fibrosis, cellular morphogenesis) are shown with asterisks. The remaining 11 genes are reported to have a role in development and/or morphogenesis in other tissues.