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Isobolograms of trybizine and the current trypanocides suramin, diminazene, and quinapyramine. Control IC50, normalized to 1 U of the IC50, refers to trybizine alone (X-axis [FIC 50, fractional IC50]) and to suramin (A), diminazene (B), and quinapyramine (C). The solid line represents the isobole of the drug combination in vitro. The dotted line joining the FICs of 1 is the isobole of an additive combination (C). A convex isobole represents an antagonistic combination (A and B).
