TABLE 5.
Activity of GM 237354 against emerging, less-common mold pathogens and dermatophytes
| Organism (no. of isolates) | MIC (μg/ml)a
|
|
|---|---|---|
| Broth | Agar | |
| Yeast-like fungi | ||
| Blastoschizomyces capitatus (2) | 1 (2) | 2 (2) |
| Geotrichum clavatum (2) | 1 (2) | ≤0.25 (2) |
| Trichosporon beigelii (5) | 0.5 (2), 2 (1), 4 (1), 8 (1) | ≤0.25 (2), 2 (2), 4 (1) |
| Dematiaceous fungi | ||
| Alternaria alternata (1) | >64 | >64 |
| Curvularia lunata (1) | >64 | >64 |
| Cladosporium carrioni (2) | 1 (2) | ≤0.25 (2) |
| Hyaline fungi | ||
| Fusarium spp. (3)b | >64 | >64 |
| Pseudallescheria boydii (5) | 0.5 (1), 2 (4) | ≤0.25 (3), 1 (1), 2 (1), |
| Zygomycetes | ||
| Absidia corymbifera (1) | 4 | 4 |
| Cunninghamella bertholletiae (1) | 2 | 4 |
| Rhizopus arrhizus (1) | 2 | 4 |
| Dermatophytes | ||
| Epidermophyton floccosum (1) | 32 | 2 |
| Microsporum canis (1) | 8 | 8 |
| Microsporum gypseum (1) | 32 | >64 |
| Trichophyton mentagrophytes (1) | 64 | 16 |
| Trichophyton rubrum (1) | 64 | >64 |
| Trichophyton verrucosum (1) | >64 | >64 |
a
Values in parentheses indicate the number of isolates for which the MIC was as indicated.
b
Fusarium spp. were represented by three strains each of F. moniliforme, F. oxyporum, and F. solani.