Table 3.
Linear Regression of the Association Between ALT, AST, GSTM1, and GSTT1 Copy Numbers and Genotypes, Eastern Ethiopia, 2020/21 (N=210)
| Copy Numbers and Genotype | ALT (U/L) | AST (U/L) | ||
|---|---|---|---|---|
| Cases | Controls | Cases | Controls | |
| β (95% CI)a | β (95% CI)a | β (95% CI)a | β (95% CI)a | |
| GSTM1 | ||||
| 0 | 1.00 | 1.00 | 1.00 | 1.00 |
| 1 | 1.18 (0.90, 1.55) | 1.09 (0.89, 1.34) | 1.25 (0.95, 1.63) | 0.99 (0.82, 1.20) |
| ≥2 | 0.69 (0.48, 0.99)* | 1.15 (0.90, 1.48) | 0.70 (0.49, 1.01) | 0.90 (0.70, 1.13) |
| Null | 1.00 | 1.00 | 1.00 | |
| Carrier | 1.01 (0.79, 1.31) | 1.11 (0.91, 1.33) | 1.05 (0.81, 1.36) | 0.96 (0.80, 1.14) |
| GSTT1 | ||||
| 0 | 1.00 | 1.00 | 1.00 | 1.00 |
| 1 | 0.89 (0.64, 1.16) | 0.89 (0.72, 1.09) | 0.81 (0.62, 1.06) | 0.93 (0.76, 1.13) |
| ≥2 | 1.01 (0.68, 1.51) | 0.68 (0.52, 1.12) | 0.61 (0.41, 0.90)* | 0.79 (0.62, 1.03) |
| Null | 1.00 | 1.00 | 1.00 | |
| Carrier | 0.91 (0.70, 1.19) | 0.84 (0.68, 1.02) | 0.76 (0.58, 0.98)* | 0.90 (0.74, 1.08) |
| Sum of GSTM1 and GSTT1b | ||||
| 0 | 1.00 | 1.00 | 1.00 | 1.00 |
| 1 | 0.83 (0.57, 1.21) | 0.79 (0.57, 1.11) | 1.19 (0.82, 1.72) | 0.86 (0.63, 1.16) |
| ≥2 | 0.83 (0.57, 1.21) | 0.86 (0.64, 1.16) | 0.82 (0.57, 1.17) | 0.84 (0.64, 1.09) |
| Null/Null | 1.00 | 1.00 | 1.00 | |
| Carrier/Carrier | 0.83 (0.59, 1.17) | 0.84 (0.63, 1.13) | 0.98 (0.68, 1.39) | 0.84 (0.64, 1.09) |
Notes: N= 210; n for cases=106; n for controls=104; *p-value <0.05; aAdjusted for age and gender; b0=GSTM10 + GSTT10, 1=GSTM10 + GSTT11 or GSTM11 + GSTT10, 2= GSTM11 + GSTT11 or GSTM10 + GSTT12 or GSTM12 + GSTT10, ≥3= GSTM10 + GSTT13 or GSTM13 + GSTT10 or GSTM12 + GSTT12 or GSTM11 + GSTT12 or GSTM12 + GSTT11 or GSTM11 + GSTT13 or GSTM13 + GSTT11.
Abbreviations: ALT, alanine aminotransferase; AST, Aspartate aminotransferase. GSTM1, glutathione S-transferase M; GSTT1, glutathione S-transferase T1; U/L, units per liter.