TABLE 3.
Noncompartmental pharmacokinetics of LY in plasma after administration of single doses to healthy rabbitsa
| Drug dose (mg/kg) | Cmaxb (ng/ml) | Cmin24b (ng/ml) | AUC0–72c (ng/ml · h) | Vb (liter) | CL (liter/h) | t1/2βc (h) |
|---|---|---|---|---|---|---|
| 1 | 3,563 ± 644 | 44 ± 22 | 10,064 ± 786 | 2.3 ± 0.18 | 0.281 ± 0.02 | 5.8 ± 0.65 |
| 5 | 16,677 ± 2,007 | 312 ± 40 | 53,146 ± 4,430 | 3.1 ± 0.10 | 0.270 ± 0.02 | 8.2 ± 0.86 |
| 10 | 27,552 ± 2,719 | 610 ± 67 | 98,059 ± 3,286 | 3.7 ± 0.22 | 0.286 ± 0.00 | 8.9 ± 0.47 |
| 20 | 51,247 ± 2,100 | 1,294 ± 166 | 197,164 ± 8,091 | 5.0 ± 0.35 | 0.291 ± 0.01 | 11.9 ± 0.35 |
a
All values are given as means ± SEMs for three rabbits.
b
P < 0.001 by Kruskal-Wallis nonparametric ANOVA for comparison of all four values.
c
P < 0.001 by Kruskal-Wallis nonparametric ANOVA for comparison of all four values and P = 0.394 by ANOVA for departure from linearity.
d
P < 0.005 by Kruskal-Wallis nonparametric ANOVA for comparison of all four values.