Studies evaluating afterload in acute brain injury patients

Reference	Patient number	Study design	Group	Technique assessment	End-point	Findings	Quality of evidence
Hadeishi et al. [49]	8	R	SAH	PAC	To assess the effects of dobutamine to treat CV	Decreased SVR	Very low
Bulters et al. [56]	71	RCT	SAH	PAC	To assess hemodynamic changes with IABP	Higher SVR during IABP	Moderate
Watanabe et al. [34]	34	P	SAH	TT	To evaluate which hemodynamic variable was associated with the occurrence of DCI	DCI was associated with increased SVR	Low
Rzheutskaya et al. [102]	13	P	TBI	TT	To evaluate hemodynamic alterations after TBI	SVRI were used to identify four different patterns of hemodynamic status	Very low
Mayer et al. [45]	72	R	SAH	Echography	To assess the impact of cardiac injury on hemodynamic and cerebral complications after SAH	Higher SVRI were found in patients developing s-VSP	Very low

P prospective, SAH subarachnoid haemorrhage, TT transpulmonary thermodilution, IABP intra-aortic balloon counterpulsation, DCI delayed cerebral infarction, SVR systemic vascular resistances, s-VSP symptomatic vasospasm, PAC pulmonary artery catheter