Studies evaluating fluid responsiveness (FR) in acute brain injury patients

Reference	Patient number	Study design	Group	Preload assessment	End-point	Findings	Quality of evidence
Berkenstadt et al. [20]	15	P	BS	SVV	To assess the accuracy of SVV to predict FR	SVV was a strong predictor of FR	Low
Li et al. [76]	48	P	BS	SVV	To assess the accuracy of SVV when compared to commonly used variables to predict FR	SVV was a strong predictor of FR	Low
Mutoh et al. [79]	16	P	SAH	SVV	To compare SVV with GEDVI to predict FR	SVV was a better predictor than GEDVI for FR	Moderate
Mutoh et al. [68]	116	RCT	SAH	GEDVI changes	To evaluate the changes in GEDVI versus PAOP/CVP to predict FR	Only changes in GEDVI after fluid loading was associated with SV changes	Moderate
Moretti et al. [77]	29	P	SAH	dICV	To evaluate the changes in SVV versus dICV to predict FR	SVV and dICV were both strong predictor of FR	Moderate
Deflandre et al. [84]	26	P	BS	ΔPP	To evaluate the changes in ΔPP versus DD to predict FR	ΔPP and DD were both strong predictor of FR	Moderate

P prospective, RCT randomized clinical trial, BS brain surgery, SAH subarachnoid haemorrhage, SVV stroke volume variation, GEDVI global end-diastolic volume index, dICV distensibility of inferior vena cava, ΔPP pulse pressure variation