TABLE 2.

Antifungal activities of dolastatin 10 and modifications b to e in the broth macrodilution assay

Organism	ATCC no. or strain designation	MIC (MFC)c of compound:
		a	b	c	d	e
Cryptococcus neoformans	66031	0.78 (1.56)	0.78 (0.78)	0.78 (0.78)	0.195 (0.39)	0.78 (1.56)
Cryptococcus neoformans	14116	3.12 (6.25)	1.56 (25)	0.78 (12.5)	1.56 (3.12)	12.5 (>50)
Cryptococcus neoformans	32045	0.78 (1.56)	0.78 (0.78)	0.78 (1.56)	0.195 (0.39)	0.78 (0.78)
Cryptococcus neoformans	90112	0.78 (1.56)	1.56 (3.12)	0.78 (0.78)	0.0975 (0.195)	1.56 (6.25)
Cryptococcus neoformansa	94-2406b	0.0487 (0.0975)
Cryptococcus neoformansa	95-2792b	0.78 (3.12)
Cryptococcus neoformansa	96-2011b	0.78 (1.56)
Cryptococcus neoformansa	94-2483b	0.195 (0.39)
Cryptococcus albidus	66030	>50
Cryptococcus albidus	34140	>50
Cryptococcus albidus	10666	>50
Cryptococcus laurentii	66036	>50
Cryptococcus laurentii	18803	>50
Cryptococcus laurentii	34142	>50
Cryptococcus uniguttulatus	34143	>50
Cryptococcus uniguttulatus	66033	>50
Cryptococcus ater	14247	>50
Candida albicans	90028	>50	>25	>25	>50	>50
Candida glabrata	90030	>50	>50	>50	>50	>50
Candida parapsilosis	22019	>50
Candida lusitaniae	42720	>50
Rhodotorula mucilaginosa	9449	>50
Aspergillus fumigatus	96918	>50
Rhizopus oligosporus	22959	>50
Pseudallescheria boydii	M1.461b	>50			>50

^aFluconazole-resistant clinical isolate (7). 

^bStrain designation. 

^cAll values are in micrograms per milliliter.