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. 2023 Aug 9;119(13):2342–2354. doi: 10.1093/cvr/cvad120

Figure 3.

Figure 3

Panx1 deletion abolishes the cardioprotective effects of IPC. Mouse hearts were subjected to three cycles of brief ischaemia (5 min) followed by reperfusion (5 min) before the period of prolonged ischaemia (30 min) and reperfusion (60 min). The recovery of LVDP (A), +dP/dt (B), –dP/dt (C), HR (D), and RPP (E) was not changed between WT (N = 9) and Panx1−/− (N = 10, unpaired t-test) mice following IPC and I/R. Moreover, no differences were observed in TTOC (F), TTMC (G), and ischaemic rigour (H) under these conditions. N = 10, unpaired t-test.