Table 1.
Main features of the 101 study patients (median, IQ25 – IQ75).
| ALL (n=101), median (IQ25; IQ75) | Non persitent GHD (n=72), median (IQ25 IQ75) | Persistent GHD (n=29), median (IQ25; IQ75) | p | |
|---|---|---|---|---|
| Gestational age (weeks) | 39.0 (38.0; 40.0) | 39.0 (38.0 40.0) | 39.0 (38.8 40.0) | 0.229 |
| Birth weight (percentile) | 39.5 (14.8;663) | 31.5 (13.3; 58.6) | 47,4 (30.1; 78.0) | 0.102 |
| Birth length (percentile) | 37.6 (7.8;54.6) | 31.0 (5.9; 66.2) | 42.6 (31.0; 57.8) | 0.352 |
| Head circumference (Percentile) | 46.2 (23.3;71.0) | 45.6 (24.7; 66.0) | 48.1 (28.9; 75.4) | 0.745 |
| SGA number (%) | 24.8 | 28.2 | 17.2 | 0.001 |
| Age at first visit (years) | 8.9 (5.4;11.6) | 8.3 (5.5;106) | 10.3 (4.5; 13.8) | 0.345 |
| Bone age at GH start (years) | 8.0 (5.0;11.0) | 7.0 (4.0;10.5) | (2.7;12.3) | 0.886 |
| Chron. age-Bone age (years) | 23 (1.5;3.4) | 2.3 (1.2; 3.4) | 1.8 (1.4; 2.5) | 0.510 |
| First IGF-1 ng/ml | 92.0 (64.0;139.0) | 92.0 (65.0;211.6) | 87.0 (43.0;125.0) | 0.049 |
| First GH stim. Peak mUI/L | 11.1 (8.0 16.0) | 12.2 (8.5 19.0) | 7.8 (4.5; 18.0) | 0.001 |
| Second IGF-1 (ng/ml) | 96.5 (63.5;150.5) | 96.0 (70.5 168.0) | 113.0 (27.5, 199.3) | 0.977 |
| Second GH stim. Peak (mUI/L) | 12.0 (8.1;15.9) | 12.8 (9.5; 17.0) | 7.1 (3.8;13.3) | 0.001 |
| Mean 1 + 2 GH Stim.peak (mUI/L) | 11.8 (8.8; 15.1) | 13.2 (10.5 15.4) | 7.9 (4.4;11.9) | 0.001 |
| Mean IGF1 1 + 2 baseline (ng/ml) | 101.8 (69.0; 144.6) | 98.0 (73.5; 152.0) | 109.5 (49.3; 183.8) | NS |
| Age at GH start (years) | 9.8 (8.8;15.1) | 10.2 (6.5; 12.3) | 10.1 (4.0; 13.3) | 0.867 |
| Height at GH start (SDS) | -2.34 (-2.78; -1.98) | -2.17 (-2.56; -1.77) | -2.66 (-2.97; -2.11) | 0.012 |
| BMI at GH start (SDS) | -0.32 (-1.00 -0.29) | -0.29 (-1.00; 0.11) | 0.08 (-0.44 0.82) | 0.032 |
| Age at Tanner2 (years) girls | 11.6 (10.1; 12.6) | 11.6 (10-4; 12.7) | 11.3 (9.9; 12.8) | NS |
| Age at Tanner2 (years) boys | 13.5 (12.6 14.5) | 13.3 (10.4 13.9) | 13.7 (12.2 14.2) | NS |
| Age at menarche (years) | 13.7 (12.8 14.6) | 13.9 (12.9; 14.8) | 12.9 (12.2 14.9) | 0.461 |
| IGF-1 after GH stop (ng/ml) | 313.0 (248.9;37 | 324.0 (269.0;388.0) | 224 (140.3; 311.5) | 0.001 |
| GH stim. peak after GH stop mUI/L | 23.7 (11.6;39.0) | 30.4 (21.4;41.3) | 8.1 (4.4;11.0) | 0.001 |
| Final height (SDS) | -0.85 (-1.40 -0.36) | -0.63 (-1.25; -0.30) | -0.79 (-1.54 -0.40) | 0.472 |
| Final weight (SDS) | -0.86 (-1.63 -0.13) | -0.89 (-1.41; -0.24) | -0.31 (-0.94 0.22) | 0.020 |
| Final BMI (SDS) | -0.40 (-1.56 0.21) | -0.59 (-1.37; 0.00) | 0.19 (-0.63 0.54) | 0.006 |
| Mother height (SDS) | -0.17 (-0.90 0.29) | -0.25 (-0.90; 0.29) | -0.02 (-0.90; 0.44) | 0.830 |
| Father height (SDS) | -0.30 (-0.85; 0.30) | -0.30 (-0.85; 0.44) | -0.30 (-0.85; 0.23) | 0.951 |
| Target height (SDS) | -0.32 (-0.87; 0.15) | -0,30 (-0.70 0.24) | -0.33 (-1.10 0.10) | 0.305 |
Bold values: p < 0.05 (significant values). NS, non significant.