Table 5.
ROC characteristics of the cytokines analysis in Omicron COVID-19 patients.
| Analytes | Cutoff (pg/mL) | Sensitivity (%) | Specificity (%) | AUC value | p-Value |
|---|---|---|---|---|---|
| IL-6 | 0.33 | 95 | 91.67 | 0.9056 | <0.0001 |
| IFN-γ | 3.48 | 100 | 86.11 | 0.9583 | <0.0001 |
| CCL-2/ MCP-1(MCAF) | 13.78 | 100 | 97.22 | 0.975 | <0.0001 |
| CCL-3/ MIP-1α | 0.25 | 100 | 88.89 | 0.9569 | <0.0001 |
| CCL-4/MIP-1β | 69.53 | 100 | 97.22 | 0.9722 | <0.0001 |
| CCL-5/RANTES | 4,547.35 | 100 | 91.67 | 0.9722 | <0.0001 |
| IL-8 | 2.61 | 100 | 97.22 | 0.9722 | <0.0001 |
Receiver operating characteristic (ROC) of the cytokines IL-6, IFN-γ, CCL-2/ MCP-1 (MCAF), CCL-3/ MIP-1α, CCL-4/MIP-1β CCL-5/RANTES, and IL-8 in plasma of Omicron-infected patients and uninfected controls. Levels of all analytes were analyzed post-log10 transformation of the observed concentrations of individual cytokine/chemokine/growth factors. The Mann–Whitney U test was used for numerical data for comparisons among the study groups. A p-value of <0.05 was considered significant. ROC analysis was performed using GraphPad Prism 8 software, AUC, area under the curve.