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. 2023 Oct 4;5(1):100244. doi: 10.1016/j.xhgg.2023.100244

Figure 1.

Figure 1

Diagram of five distinct TP53 p.R337H alleles

(A) Five distinct haplotypes were identified based on TP53 internal polymorphisms and microsatellite markers on chromosome 17p13.

(B) Identical DNA sequences shared among the five haplotypes are identified by solid blue bars and blue dashed lines. Polymorphic markers distinguishing the five haplotypes are highlighted in purple [Hap3, VNTRp53(n) and p53CA(n)], red [Hap4 P72R, PIN3, VNTRp53(n) and p53CA(n)], orange (Hap5, de novo, P72/A2), and green (Hap1, DNA sequence spanning D17S796 to D17S952 containing XAF1 p.E134∗ variant) solid bars.