Table 4.
Derivation group. MR imaging and UDC parameters demonstrating the differences between simple steatosis and NASH of 46 patients with NAFLD according to the SAF score for both readers (R1 and R2) using the t-test
| Parameter | Simple steatosis 18 patients R1 |
NASH 28 patients R1 |
†p value | Simple steatosis 18 patients R2 |
NASH 28 patients R2 |
†p value | ICC |
|---|---|---|---|---|---|---|---|
| UDC (unenhanced T1 and Gd-EOB-DTPA-T1-HBP) | 0.36 ± 0.23 | 0.71 ± 0.24 | < 0.001 | ||||
| UDC (CSI, in- and opposed-phase) | 0.48 ± 0.27 | 0.67 ± 0.27 | 0.02 | ||||
| Mean signal intensity unenhanced T1 | 285.73 ± 52.76 | 266.54 ± 43.15 | 0.539 | 251.16 ± 66.14 | 244.33 ± 46.19 | 0.266 | 0.813 |
| Mean signal intensity Gd-EOB-DTPA-T1-HBP | 761.48 ± 240.40 | 528.12 ± 83.67 | 0.001 | 652.62 ± 22.15 | 454.61 ± 19.11 | 0.044 | 0.958 |
| Mean relative liver enhancement (RLE) | 1.58 ± .52 | 1.01 ± .27 | < 0.001 | 1.49 ± .43 | 1.12 ± .41 | 0.005 | 0.784 |
| FF (PDFF/CSI, in- and opposed-phase) | 24.53 ± 6.83 | 50.56 ± 19.01 | 0.004 | 22.82 ± 17.52 | 39.82 ± 19.26 | 0.005 | 0.980 |
*Data are means with standard deviations
†If the p value was less than the conventional level of .05, the corresponding variable was statistically significant and is written in bold type
RLE, relative liver enhancement; FF, fat fraction; CSI, chemical shift imaging dual echo: in-phase and out-of-phase; UDC (unenhanced T1 and HBP): unsupervised deep clustering derived from unenhanced T1 and T1, 20 min after injection of Gd-EOB-DTPA acid in the hepatobiliary phase (HBP); UDC (CSI, in- and opposed-phase), unsupervised deep clustering derived from chemical shift imaging (in-phase and out-of-phase)
All 4 values in the last column are significant since p < 0.05