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. Author manuscript; available in PMC: 2024 Dec 1.
Published in final edited form as: Neuropharmacology. 2023 Sep 27;240:109732. doi: 10.1016/j.neuropharm.2023.109732

Figure 8. No changes in adult methamphetamine potentiation of brain stimulation reward as measured via intracranial self-stimulation (ICSS) following once daily morphine (15 mg/kg, s.c.) from P1-P14. A-D.

Figure 8.

Total rewards delivered, total rewards delivered as % vehicle, total responses for stimulation, total responses for stimulation as % vehicle, respectively. No effect of Morphine Treatment or interactions with Methamphetamine Dose for any of these measures. There was a significant effect of Methamphetamine Dose on total rewards (A: ***p = 0.001) and total responses (C: **p = 0.007), indicating methamphetamine-induced potentiation of brain stimulation reward. Data are plotted as the mean ± S.E.M. Sample sizes are shown in panel A next to the figure legend. Sample size by Sex: SAL: n = 10 (6 females, 4 males); MOR: n = 10 (7 females, 3 males).