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. 2023 Oct 10;14:1242615. doi: 10.3389/fneur.2023.1242615

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Copyright © 2023 Kitazaki, Ikawa, Hamano, Sasaki, Yamaguchi, Enomoto, Shirafuji, Hayashi, Yamamura, Tsujikawa, Okazawa, Kimura and Nakamoto.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Box plot of the normalized values of arterial spin labeling (ASL)-cerebral blood flow (CBF) (N = 10; A), single-photon emission computed tomography (SPECT) (N = 8; B), and positron emission tomography (PET) (N = 3; C) in the DWI-High and DWI-Normal regions in patients with Creutzfeldt–Jakob disease (CJD). The mean ASL-CBF, SPECT, and PET values in the DWI-High regions were significantly reduced compared with those in the DWI-Normal regions (p < 0.001 for all) (A–C). A t-test was used to evaluate the differences between the DWI-High and DWI-Normal regions. ^aValue of p of t-test <0.001, compared with DWI-Normal.