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. 2023 Oct 10;14:1242615. doi: 10.3389/fneur.2023.1242615

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Copyright © 2023 Kitazaki, Ikawa, Hamano, Sasaki, Yamaguchi, Enomoto, Shirafuji, Hayashi, Yamamura, Tsujikawa, Okazawa, Kimura and Nakamoto.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Box plots of the normalized arterial spin labeling (ASL)-cerebral blood flow (CBF) values of patients with Creutzfeldt–Jakob disease (CJD) (N = 10), HC subjects (N = 18), and patients with autoimmune encephalitis (AE) (N = 3) in the DWI-High region. The mean normalized ASL-CBF values of patients with CJD were significantly lower than those of HC subjects and patients with AE, for each (p < 0.001, respectively). Bonferroni correction for multiple comparisons were applied to evaluate the differences in the normalized ASL-CBF values. ^aValue of p < 0.001, compared with patients with CJD.