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. 2023 Oct 10;14:1242615. doi: 10.3389/fneur.2023.1242615

Table 2.

The overall agreement rate between DWI and ASL-CBF values (N = 10), SPECT values (N = 8), and PET values (N = 3) was calculated using the following formula described previously by Kundel et al. (29) in all patients with CJD.

DWI values Overall agreement rate Kappa statistic 95% CI
High Normal
ASL-CBF
values
(N = 10)
Hypoperfusion 37
(6.0%)
58
(9.4%)
81.8% 0.29 0.19–0.39
Normal 55
(8.9%)
490
(75.8%)
SPECT
values
(N = 8)
Hypoperfusion 30
(6.0%)
40
(8.1%)
85.2% 0.37 0.25–0.48
Normal 33
(6.7%)
393
(79.2%)
PET
values
(N = 3)
Low accumulation 11
(5.9%)
25
(13.4%)
78.5% 0.23 0.06–0.40
Normal 15
(8.1%)
135
(72.6%)

Cohen’s kappa coefficient with a 95% confidence interval (CI) was derived based on the overall agreement rates. ASL, arterial spin labeling; CBF, cerebral blood flow; CI, confidence interval; CJD, Creutzfeldt–Jacob disease; DWI, diffusion–weighted image; PET, positron emission tomography; SPECT, single-photon emission computed tomography.