TABLE 2.

Examples of commercially available reconstructed human pigmented epidermis models.

Reconstructed human pigmented epidermis models
Name	Manufacturer	Description
SkinEthic™ RHPE	Episkin	Reconstructed human pigmented epidermis consisting of normal human keratinocytes cultivated in the presence of melanocytes from phototype II, IV, or VI donors, localized in the basal layer in a 9-mm diameter transwell
Phenion® epiCS-M	Phenion	Highly differentiated model of the human epidermis consisting of human keratinocytes and melanocytes cultured in a 9-mm diameter transwell
MelanoDerm™	MatTek	Normal, human-derived keratinocytes and melanocytes cultured in a 9-mm diameter transwell to form a multilayered, highly differentiated model of the human epidermis. Melanocytes from individual Caucasian, African American, or Asian donors available. Three pigmentation media containing varying levels of β-FGF and α-MSH are available

Information provided on vendor websites, as of September 2023; β-FGF, beta-fibroblast growth factor; α-MSH, alpha-melanocyte-stimulating hormone.