TABLE 2.
Fungicidal or fungistatic activities of amphotericin B, itraconazole, and voriconazole against Aspergillus and Candida speciesa
| Microorganism | 105 CFU/ml at T0 | 105 CFU/ml at T24 (% change)b
|
||
|---|---|---|---|---|
| AMB | ITZ | VCZ | ||
| A. fumigatus(n = 5) | 8.52 ± 2.67 | 0.071 ± 0.091 (−99.2) | 0.195 ± 0.297 (−97.7) | 0.096 ± 0.055 (−98.9) |
| A. niger(n = 5) | 4.19 ± 1.85 | 0.074 ± 0.097 (−98.2) | 0.541 ± 0.349 (−87.1) | 0.224 ± 0.140 (−94.7) |
| A. flavus(n = 5) | 9.06 ± 4.78 | 0.173 ± 0.288 (−98.1) | 0.317 ± 0.223 (−96.5) | 0.376 ± 0.243 (−95.9) |
| Aspergillus sp. (n = 3) | 5.57 ± 5.08 | 0.081 ± 0.123 (−98.5) | 0.207 ± 0.284 (−96.3) | 0.052 ± 0.023 (−99.1) |
| C. albicans | 7.35 ± 0.68 | 0.00005 (−100) | 65.3 ± 5.2 (+788.4) | 50 ± 7.2 (+580.2) |
| C. guilliermondii | 12.3 ± 4.2 | 0.00005 (−100) | 16.3 ± 7.7 (+32.5) | 19.2 ± 15.6 (+56.1) |
| C. lusitaniae | 8.5 ± 2.12 | 0.028 ± 0.012 (−99.7) | 20.1 ± 5.9 (+136.5) | 131 ± 39 (+1,441.2) |
| C. parapsilosis | 4.0 ± 1.4 | 0.129 ± 0.026 (−96.8) | 12.8 ± 0.28 (+220.0) | 13.2 ± 2.9 (+230) |
| C. kefyr | 25.0 ± 2.4 | 0.092 ± 0.025 (−99.6) | 60.5 ± 20.5 (+142) | 66 ± 19 (+164) |
| C. stellatoidea | 12.5 ± 4.2 | 0.00005 (−100) | 84.0 ± 21.4 (+572) | 108 ± 43 (+764) |
| C. tropicalis | 11.7 ± 2.5 | 0.0067 (−99.9) | 137 ± 65 (+1,070.9) | 150 ± 37 (+1,182.1) |
| C. glabrata | 7.0 ± 0 | 0.00005 (−100) | 152 ± 30 (+2,071.4) | 46.5 ± 23.3 (+564.3) |
a
Results shown are from a typical experiment. Each value represents the mean of two independent determinations. T0 and T24 denote the times immediately prior to and 24 h after addition of the antifungal agent, respectively.
b
Percent change is the decrease or increase from the original inoculum (T0). AMB, amphotericin B; ITZ, itraconazole; VCZ, voriconazole. All drugs were used at 5 μg/ml.