. 2023 Oct 11;4:1281698. doi: 10.3389/fpain.2023.1281698

Table 1.

P-values for t-test comparisons of effects produced by vehicle alone vs. vehicle + 0.56% IP acid in cohorts of mice used for each of the 15 drugs evaluated in this study.

Drug cohort	Crosses	Movement	Bias
Ketoprofen	0.0045^*	<0.0001^*	0.1837
Fentanyl	0.0001^*	<0.0001^*	0.9408
Morphine	0.0224^*	<0.0001^*	0.0009^*
Buprenorphine	0.0004^*	<0.0001^*	0.0891
Nalbuphine	<0.0001^*	<0.0001^*	0.0716
NAQ	0.0007^*	<0.0001^*	0.1139
Naltrexone	<0.0001^*	<0.0001^*	0.1348
56:1 Fent/NTX	<0.0001^*	<0.0001^*	0.3097
32:1 Fent/NTX	<0.0001^*	<0.0001^*	0.8595
18:1 Fent/NTX	<0.0001^*	<0.0001^*	0.4475
10:1 Fent/NTX	0.0007^*	<0.0001^*	<0.0001^*
Diazepam	0.0113^*	<0.0001^*	0.0161^*
U69593	0.0003^*	<0.0001^*	0.0001^*
Psilocybin	<0.0001^*	<0.0001^*	0.0354^*
Amphetamine	<0.0001^*	<0.0001^*	0.0789

Relative to effects of vehicle alone, vehicle + 0.56% IP acid significantly decreased crosses and movement in each cohort of mice, whereas bias was significantly affected in only a subset of cohorts.

Asterisk indicates that p-value met the criterion for significance of p < 0.05.