Table 2.
One-way ANOVA or t-test results for each drug administered alone or as a pretreatment to 0.56% IP acid on crosses and movement.
| Drug | ± IP acid | Crosses | Movement | Figure |
|---|---|---|---|---|
| Ketoprofen | Alone | F(4,55) = 1.65, p = 0.1742 | F(4,55) = 4.33, p = 0.0041^ | 3 |
| + IP acid | F(4,55) = 5.01, p = 0.0016* | F(4,55) = 18.02, p < 0.0001*-F | ||
| Fentanyl | Alone | F(4,55) = 11.12, p < 0.0001* | F(4,55) = 1.28, p = 0.2874 | 4 |
| + IP acid | F(4,55) = 1.36, p = 0.2599 | F(4,55) = 7.79, p < 0.0001* | ||
| Morphine | Alone | F(4,55) = 4.86, p = 0.0020* | F(4,55) = 2.28, p = 0.0726 | 4 |
| + IP acid | F(5,66) = 3.02, p = 0.0162* | F(5,66) = 3.27, p = 0.0107* | ||
| Buprenorphine | Alone | F(4,55) = 3.44, p = 0.0139* | F(4,55) = 0.48, p = 0.7481 | 4 |
| + IP acid | F(6,77) = 2.92, p = 0.0126* | F(6,77) = 6.83, p < 0.0001* | ||
| Nalbuphine | Alone | F(4,55) = 1.78, p = 0.1453 | F(4,55) = 3.25, p = 0.0184^ | 5 |
| + IP acid | F(4,55) = 0.47, p = 0.7610 | F(4,55) = 0.95, p = 0.4424 | ||
| NAQ | Alone | F(4,55) = 0.72, p = 0.5850 | F(4,55) = 0.66, p = 0.6208 | 5 |
| + IP acid | F(4,55) = 0.12, p = 0.9742-m | F(4,55) = 0.87, p = 0.4902-F | ||
| Naltrexone | Alone | t = 0.27, df = 22, p = 0.7934-m | t = 0.64, df = 22, p = 0.5305 | 5 |
| + IP acid | t = 0.67, df = 22, p = 0.5079 | t = 0.26, df = 22, p = 0.7952 | ||
| 56:1 Fent/NTX | Alone | F(4,55) = 0.12, p = 0.9742 | F(4,55) = 0.27, p = 0.8972 | 6 |
| + IP acid | F(4,55) = 3.729, p = 0.0094* | F(4,55) = 14.59, p < 0.0001*-m | ||
| 32:1 Fent/NTX | Alone | F(4,55) = 0.14, p = 0.9648 | F(4,55) = 0.35, p = 0.8408 | 6 |
| + IP acid | F(4,55) = 3.07, p = 0.0236* | F(4,55) = 6.51, p = 0.0002* | ||
| 18:1 Fent/NTX | Alone | F(4,55) = 0.42, p = 0.7968 | F(4,55) = 0.31, p = 0.8704 | 6 |
| + IP acid | F(4,55) = 2.17, p = 0.0841 | F(4,55) = 3.44, p = 0.0139* | ||
| 10:1 Fent/NTX | Alone | F(4,55) = 0.25, p = 0.9080 | F(4,55) = 0.45, p = 0.7745-F | 6 |
| + IP acid | F(4,55) = 0.81, p = 0.5222 | F(4,55) = 1.45, p = 0.2290 | ||
| Diazepam | Alone | F(5,66) = 12.98, p < 0.0001* | F(5,66) = 19.24, p < 0.0001*-f | 7 |
| + IP acid | F(5,66) = 4.20, p = 0.0022* | F(5,66) = 10.55, p < 0.0001* | ||
| U69593 | Alone | F(3,44) = 7.54, p = 0.0004*-M | F(3,44) = 13.38, p < 0.0001*-f | 7 |
| + IP acid | F(4,55) = 0.08, p = 0.9887 | F(4,55) = 0.40, p = 0.8099 | ||
| Psilocybin | Alone | F(4,55) = 2.45 p = 0.0569 | F(4,55) = 11.92, p < 0.0001*-m | 7 |
| + IP acid | F(5,66) = 1.16, p = 0.3359 | F(5,66) = 1.80, p = 0.1241 | ||
| Amphetamine | Alone | F(4,55) = 2.57, p = 0.0478^ | F(4,55) = 1.94, p = 0.1368 | 7 |
| + IP acid | F(3,44) = 6.88, p = 0.0007* | F(3,44) = 19.10, p < 0.0001* |
Upper case letters (M,F) or lower case letters (m,f) indicate a Sex × Dose interaction (upper case) or main effect of Sex (lower case), with the letter indicating whether males (M,m) or females (F,f) showed higher scores. See Supplementary Data for detailed report of statistical analysis for sex differences.
*
Asterisk indicates a significant drug effect with Dunnett's post hoc test showing that at least one drug dose produced an effect different from vehicle as indicated by filled points in Figures 3–7.
^
Caret indicates a significant ANOVA but no difference between vehicle and drug doses by Dunnett's post hoc test.