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. 2023 Oct 11;14:1264877. doi: 10.3389/fmicb.2023.1264877

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Copyright © 2023 Heiman, Vacheron and Keel.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Model of R-tailocin regulation in Pseudomonas aeruginosa under non-inducing (A) and inducing (B) conditions. (A) Under non-inducing conditions, the tailocin locus-associated repressor PrtR inhibits the expression of the tailocin activator PrtN. (B) Upon DNA damage, RecA forms nucleoprotein filaments on single-stranded DNA, which stimulates the autocleavage of the PrtR repressor, resulting in the derepression of the activator PrtN and the expression of the genes within the tailocin cluster. Sharp arrows represent activation of gene expression, the blunt-arrow represent inhibition of gene expression and the dashed-line arrow represents degradation.