Table 3.
Adverse events analysis based on neoadjuvant chemoradiotherapy and surgery.
| IFI (n=102) | ENI (n=165) | p-value | |
|---|---|---|---|
| n (%) | n (%) | ||
| nCRT-related events | |||
| Anemia† | 2(2) | 2(1.2) | .625 |
| Thrombocytopenia† | 2(2) | 4(2.4) | .804 |
| Leukopenia§ | 35(34.3) | 36(21.8) | .025 |
| Neutropenia§ | 30(29.4) | 23(13.9) | .002 |
| G4 Lymphopenia | 23(21.5) | 41(25.2) | .406 |
| ΔALC, 109/L, IQR | 0.79(0.51-1.06) | 1.01(0.62-1.30) | .019 |
| Pericardial effusion* | 18(17.6) | 50(30.3) | .021 |
| Arrhythmia* | 12(11.8) | 24(14.6) | .583 |
| Radiation pneumonitis* |
12(11.8) | 44(26.7) | .004 |
| Radiation esophagitis* | 13(12.7) | 19(11.5) | .102 |
| Surgery-related events | |||
| Bleeding, ml, IQR | 50(50-100) | 50(50-100) | .338 |
| Surgery duration, min, IQR |
270(240-296) | 275(240-332) | .168 |
| Fistula† | 3(2.9) | 17(10.3) | .026 |
| ARDS† | 1(1) | 2(1.2) | .861 |
| Pleural effusion* | 11(10.8) | 16(9.7) | .775 |
| Pneumothorax¶ | 26(25.5) | 43(26.1) | .918 |
| Atelectasis¶ | 18(17.6) | 38(23) | .294 |
| Anastomotic stenosis¶ | 38(37.3) | 54(32.7) | .449 |
| 30 days re-hospitalization |
4(3.9) | 6(3.6) | .905 |
| Death after 30 days | 2(2) | 2(1.2) | .625 |
IFI, involved-field irradiation; ENI, elective nodal irradiation; nCRT, neoadjuvant chemoradiotherapy; ALC, absolute lymphocyte count; G4, grade 4; ΔALC= [mean ALC pre-nCRT] – [mean ALC post-nCRT]; IQR, interquartile range; ARDS, acute respiratory distress syndrome. †, Events of grade ≥3 according to CTCAE 5.0. §, Events of grade ≥3 with fever or grade 4 according to CTCAE 5.0. *, Events of grade ≥2 according to CTCAE 5.0; ¶, Events of any grade according to CTCAE 5.0.