Table 4.
Logistic regression analysis of grade 4 (G4) lymphopenia during nCRT.
| Variables | Univariate analysis | |
|---|---|---|
| OR (95% CI) | p-value | |
| ENI vs. IFI | 0.754(0.387-1.469) | .406 |
| PTV, cm3 | 1.003(1.001-1.005) | .004 |
| Heart | ||
| MHD, Gy | 1.099(1.023-1.180) | .010 |
| HV5 | 1.025(0.998-1.052) | .068 |
| HV10 | 1.025(1.002-1.049) | .033 |
| HV20 | 1.026(1.003-1.048) | .024 |
| HV30 | 1.040(1.008-1.074) | .014 |
| Lung | ||
| MLD, Gy | 1.010(0.976-1.045) | .574 |
| LV5 | 1.045(1.005-1.085) | .026 |
| LV10 | 1.048(1.002-1.095) | .039 |
| LV20 | 1.080(1.017-1.147) | .012 |
| LV30 | 1.094(1.013-1.181) | .022 |
PTV, planning target volume; ENI, elective-nodal irradiation; IFI, involved-field irradiation; nCRT, neoadjuvant chemo-radiotherapy; OR, odds ratio; CI, confidence interval; MHD, mean heart dose; MLD, mean lung dose; Vx, the percentage of lung/heart volume receiving ≥x Gy.