Table 2.
Conventional biomarkers of renal response.
| Complete response | Partial response | Non-response | p-value | |
|---|---|---|---|---|
| N (%) | 12 (57) | 3 (14) | 6 (29) | – |
| Age | 27 [24, 30] | 35 [31, 39] | 0.07 | |
| Baseline SLEDAI score | 11 [9, 18] | 9 [7, 13] | 0.14 | |
| Renal activity index* | 56 [28, 69] | 66 [56, 70] | 0.61 | |
| Renal chronicity index* | 23 [8, 34] | 30 [26, 31] | 0.73 | |
| Laboratory data | ||||
| Serum albumin (g/dL) | 29 [23, 34] | 28 [25, 30] | 0.87 | |
| Estimated (e) GFR (mL/min/1,73 m2) | 90 [74, 90] | 82 [73, 90] | 0.97 | |
| UPCR (g/g creatinine) | 2.0 [1.3, 3.6] | 2.5 [1.3, 4.1] | 0.49 | |
Complete renal response: UPCR < 0.5 g/g and eGFR ≥ 60 ml/min, or if < 60 ml/min at baseline with no decline >20% compared to baseline; Partial renal response: 50% improvement in UPCR and UPCR between 0.5 and 3 g/g and stabilization (< 20% decrease) of eGFR. Values are given as median [interquartile range]. *Complete response vs. partial- or non-response among active LN only (n = 13, class III or IV ± V), Mann-Whitney test.