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. 2023 Oct 11;6:1222612. doi: 10.3389/frai.2023.1222612

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Copyright © 2023 Chaudhuri, Pash, Hormuth, Lorenzo, Kapteyn, Wu, Lima, Yankeelov and Willcox.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Change in TTP α-superquantile when using optimal treatment regimens as compared to SOC for (A) early progressors: 16 patients with TTP α-superquantile <1 month after end of RT and (B) intermediate progressors: 62 patients with TTP α-superquantile between 1 and 3 months after end of RT. Median values are indicated in text above each box plot. The solution of the optimization problem in Equation (12) with D_max = X Gy is indicated as “OUU: X Gy”. The median change indicates longer TTP compared to the SOC when optimal treatments are used.