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. 2023 Oct 11;6:1222612. doi: 10.3389/frai.2023.1222612

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Copyright © 2023 Chaudhuri, Pash, Hormuth, Lorenzo, Kapteyn, Wu, Lima, Yankeelov and Willcox.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Illustration of TTP and use of negative TTP as QoI. (A) Visual representation of TTP for various trajectories obtained from n_MC Monte Carlo samples of θ, (B) histogram of samples of T_TTP(u, θ), and (C) histogram of samples of QoI −T_TTP(u, θ) along with the estimated risk with α = 0.95.