Figure 4.

Predictive digital twin timeline for HGG patients. The predictive digital twin features a personalized risk-based strategy to optimize the adaptive RT regimen under uncertainty. This strategy is constructed assuming a standard collection of MRI data during the course of the clinical management of HGG after surgery, whereby MRI scans are prescribed after the surgical intervention (day 0), before the onset of RT (day 20), and during the second week of the RT regimen (day 27). On day 27, the digital twin is calibrated using the MRI data and then the risk-aware treatment plan is solved using the calibrated model and deployed for the remaining five weeks of RT.