Figure 1.

Graphical depiction of microtubule target and α/β-tubulin monomer units with 3D structural overlay (gray) with antimitotic ligands cocrystallized in their respective binding pockets highlighted. Taxol complex (blue, PDB: 1JFF)⁹ with the vinblastine complex (orange, PDB: 1Z2B)¹⁰ superimposed onto the (yellow, PDB: 1SA0)¹¹ colchicine-DAMA complex. red, GTP (Guanosine-5′-triphosphate) substrate. Graphic made in PyMOL.¹²